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KMID : 0604620060130020023
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Dongguk Journal of Medicine
2006 Volume.13 No. 2 p.23 ~ p.32
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Neuroprotective Effects of Erythropoietin in Ischemic Core and Penumbra following Ischemia-Reperfusion
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Chun Bum-Soo
Ko Bok-Hyun
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Abstract
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Erythropoietin (EPO) primarily is produced in the kidney and acts as a principal mediator of the physiologic response to ischemia by increasing red blood cell production. EPO appears to play a neuroprotective role based on preclinical data demonstrating the ability of recombinant human erythropoietin (r-Hu-EPO) to shield neurons from ischemic stress when administered intracerebroventriculaly, In CNS models, systemically administered r-Hu-EPO has not been intensely investigated because large glycosylated molecules generally were deemed incapable of crossing the blood-brain barrier (BBB). In this study, administration of r-Hu-EPO 4 days intraperitoneally after ischemia-reperfusion injury increased the numbers of neuronal nuclei (NeuN) and glial fibrillary acidic protein (GFAP) positive cells in the ischemic cortical core compared with that of the ischemia-reperfusion without r-Hu-EPO. Furthermore, the expression of CNPase in the ischemic cortical penumbra under the r-Hu-EPO treatment was significantly increased compared with that of the ischemia-reperfusion without r-Hu-EPO. These results suggest that given r-Hu-EPO may have therapeutic potential for stroke via neuroprotection even systemically administered.
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KEYWORD
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erythropoietin, systemic administration, neuroprotection
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